Transforming Growth Factor-ß Signaling in Bladder Fibrosis. doi: http://dx.doi.org/10.5016/1806-8774.2008.v10p1

Authors

  • Govindaraj Anumanthan Research Fellow
  • John C Pope IV Associate Professor

DOI:

https://doi.org/10.5016/1806-8774.2008.v10p1

Keywords:

transforming growth factor-ß, fibrosis, bladder, MAPK, collagen

Abstract

Abstract In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix. These cooperative interactions involve numerous cytokines acting through specific cell-surface receptors. When the balance between the cells and the extracellular matrix is perturbed, disease can result. This is clearly evident in the interactions mediated by the cytokine transforming growth factor-ß (TGF-ß). TGF-ß signaling has been studied extensively in fibrotic disease of lung, liver, skin, and kidney. However, little is known about the role of TGF-ß in bladder fibrosis. This review focuses on the mechanisms underlying TGF beta expression and how it relates to fibrotic processes in bladder.

Author Biographies

Govindaraj Anumanthan, Research Fellow

Govindaraj Anumanthan, Ph.D Department of Urologic Surgery, A-1302, Medical Center North, 1161, 21st Avenue South, Nashville, Tennessee 37232 Phone: 615-343-0450 Fax: 615-322-5869 E-mail: govindaraj.anumanthan@vanderbilt.edu

John C Pope IV, Associate Professor

John C. Pope IV, M.D. Associate Professor, Urologic Surgery and Pediatrics Vanderbilt Children's Hospital 4102 Doctor's Office Tower 2200 Children's Way Nashville, TN 37232-9820 Pager/Mobile: 615.400.8488 Phone: 615.936.1060 Fax: 615.936.1061

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Published

2008-02-07

Issue

Vol. 10 (2008)

Section

Reviews

License

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