Nasopharyngeal Carcinoma: an Enigmatic Tumor. doi: http://dx.doi.org/10.5016/1806-8774.2008.v10p27

Authors

  • Wei-Lin Tay Department of Anatomy, National University of Singapore
  • Puay-Hoon Tan Singapore General Hospital
  • George Wai-Cheong Yip Department of Anatomy, National University of Singapore
  • Boon-Huat Bay Department of Anatomy, National University of Singapore

DOI:

https://doi.org/10.5016/1806-8774.2008.v10p27

Abstract

Nasopharyngeal cancer (NPC) is endemic in Southern China and South East Asia but is rare in the West. Men have a two to three times higher risk of developing the disease than women. NPC has been classified by the World Health Organization (WHO) into three categories based on the degree of differentiation, with WHO Type 3 being the most common histopathological type in endemic areas. The multifactorial etiologies of NPC include genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental and dietary factors. Genetic linkage or association studies have demonstrated a correlation between the HLA haplotype and NPC susceptibility. Higher EBV antibody titers have been observed in most patients with undifferentiated NPC compared with normal controls. Consumption of salted fish containing volatile nitrosamines, especially during childhood, has been implicated as a possible factor contributing to NPC. The most common presenting symptom is enlarged cervical lymph nodes and patients may also have nasal, otological and neurological symptoms. Radiotherapy remains the main modality of treatment for this cancer.

Author Biographies

Wei-Lin Tay, Department of Anatomy, National University of Singapore

Researcher

Puay-Hoon Tan, Singapore General Hospital

Head, Department of Pathology

George Wai-Cheong Yip, Department of Anatomy, National University of Singapore

Assistant Professor, Department of Anatomy

Boon-Huat Bay, Department of Anatomy, National University of Singapore

Assoc Professor, Department of Anatomy (Professor with effect from 1st January 2008) Assistant Dean (Graduate Studies) Yong Loo Lin School of Medicine

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Published

2008-02-18

Issue

Vol. 10 (2008)

Section

Reviews

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