Aging Changes of Macromolecular Synthesis in the Mitochondria of Mouse Hepatocytes as Revealed by Microscopic Radioautography. doi: http://dx.doi.org/10.5016/1806-8774.2007v9p30

Authors

  • Tetsuji Nagata

DOI:

https://doi.org/10.5016/1806-8774.2007v9p30

Abstract

This mini-review reports aging changes of macromolecular synthesis in the mitochondria of mouse hepatocytes. We have observed the macromolecular synthesis, such as DNA, RNA and proteins, in the mitochondria of various mammalian cells by means of electron microscopic radioautography technique developed in our laboratory. The number of mitochondria per cell, number of labeled mitochondria per cell with 3H-thymidine, 3H-uridine and 3H-leucine, precursors for DNA, RNA and proteins, respectively, were counted and the labeling indices at various ages, from fetal to postnatal early days and several months to 1 and 2 years in senescence, were calculated, which showed variations due to aging.

Downloads

Published

2007-12-11

Issue

Vol. 9 (2007)

Section

Reviews

License

Disclaimer The Publisher does not assume responsibility for any injury and/or damage to persons or property as a matter of product liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the reviews published by ARBS. All procedures reported are expected to conform to ethical standards; inclusion in the journal does not constitute a guarantee or endorsement of the quality or value of such procedures. Copyright Submission of a review to this periodical will be taken to imply that it represents an original unpublished text, not under consideration for publication elsewhere. Written permission to publish illustrations must be obtained by the corresponding author before submission and any acknowledgment should be included in figure captions. Terminology: Abbreviations, Acronyms, Eponyms, and Nomenclature - Define ALL abbreviations, acronyms and names of genes, gene products, proteins, and protein products at first mention. Do not use abbreviations in titles. Only universally accepted abbreviations may be used without definition. - Observe species-appropriate rules of nomenclature formatting with respect to use of upper and lower case letters and italics for both gene and protein designations. - Avoid beginning sentences with very short abbreviations or acronyms, especially those that begin with a lower case letter (such as hCG, mRNA, etc.; use “Human CG”, “Messenger RNA”, etc., in the latter instances). - Do not use the possessive form in eponymous terms: use Dulbecco Modified Eagle medium, not Dulbecco's Modified Eagle's medium; Hanks solution, not Hanks' solution; etc.