Story of Muscarinic Receptors, Alkaloids with Muscarinic Significance and of Muscarinic Functions and Behaviors.

Alexander George Karczmar


This review of the studies of the muscarinic receptors, their synaptic activities and their functional and behavioral roles will begin with the history of the research of the autonomic and central nervous systems and their transmitters, the development of the notion of the receptor, and the tale of the significance of muscarine and other alkaloids as well as of organophosphorus (OP) anticholinesterases for these studies; we will then segue into the modern status of muscarinic receptors and of their functional and behavioral expression.

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